Point of care approaches to 3D bioprinting for wound healing applications

Abstract In the quest to improve both aesthetic and functional outcomes for patients, clinical care of full-thickness cutaneous wounds has undergone significant development over past decade. A shift from replacement regeneration prompted skin substitute products, however, inaccurate replication host tissue properties continues stand in way realising ultimate goal scar-free healing. Advances three-dimensional (3D) bioprinting biomaterials used engineering have converged recent years present opportunities progress this field. However, many proposed strategies wound healing involve lengthy in-vitro cell culture construct maturation periods, employ complex deposition technologies, lack credible point (POC) delivery protocols. In-situ is an alternative strategy which can combat these challenges. order survive journey bedside, printing protocols must be curated, biomaterials/cells selected facilitate intraoperative delivery. review, current status in-situ 3D systems applications discussed, highlighting methods employed, biomaterials/cellular components utilised anticipated translational We believe that with growth collaborative networks between researchers, clinicians, commercial, ethical, regulatory experts, potential transform POC treatment.